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drugs / antidepressants / other classifications

Various classifications of antidepressants
(Wellbutrin, Zyban, Champix)



Mental health problems

  • Symptoms of Depression

  • Adjuvant/stimulant (combined with other antidepressants)

  • Attention Deficit-Hyperactivity Disorder


Physical health issues

  • Nicotine addiction

  • Sexual problems



Physical health issues

  • people with allergies

  • History of seizures

  • Kidney or liver problems: reduced doses and close monitoring. If severe kidney or liver problems: refrain


Mental health problems

  • Anorexia and bulimia

  • Severe insomnia

  • History of mania episodes



Reduced doses


Children and teenagers

Use with caution as may activate suicidal thoughts; efficacy and safety have not been demonstrated


Pregnancy and breast feeding

Safe during pregnancy and breastfeeding

Side effects

They depend on the dosage and duration of treatment, the metabolism of the individual and the context in which he lives.


Common side effects


  • Headache

  • Dizziness

  • Dizziness

  • Dry mouth

  • Hustle

  • Tinnitus

  • Confusion



  • Nausea

  • Abdominal pain

  • Constipation



  • Loss of appetite

  • Weightloss








Less common side effects



Epileptic seizures



  • State of mania or hypomania

  • Suicidal thoughts in children and adolescents

  • Anxiety



Muscle aches



  • High blood pressure (may be serious)

  • Allergic reactions




Interactions with drugs and with other substances


Mental health problems

  • Raises concentrations of tricyclic antidepressants

  • Higher dose of Wellbutrin when prescribed with Tegretol

  • Increases the effect of Haldol

  • With MAOI antidepressants, can be fatal.

  • Stop taking MAOIs for at least 2 weeks

  • With antidepressants, lithium and some antipsychotics (or neuroleptics), may increase risk of seizures


physical health problem

Close monitoring if prescribed with warfarin (Coumadin)  because it can cause blood problems



  • With alcohol, valerian, St. John's wort, kava kava (pear tree), increased central nervous system depressant effects

  • Wellbutrin, Zyban and Champix can increase the effects of alcohol

Overdose Risks


  • Rarely fatal

  • Difficulty breathing

  • Lack of coordination

  • Seizures

  • Heart problems

  • Hallucinations

  • Loss of consciousness

Withdrawal symptoms

Psychotropic drugs act in the brain just as they do in the rest of the body; and as we have seen, each person reacts differently. It's the same with weaning; the person's metabolism, the type of drug, the dose as well as the duration of the intake and its half-life, explain that the withdrawal effects are varied. We have listed the potential and main withdrawal symptoms of each class of psychotropic drugs. This list is incomplete, as not all withdrawal effects are listed; moreover, knowledge is rapidly evolving in this field. A person may have no withdrawal symptoms or experience one, a few, or even many. The medication reduction journey is specific to each person, just as each process is unique. For example, a person can take the same medicine twice at the same dose and the effects will be different. Gradual reduction, like removing 10  % of dose per week/month, reduces the frequency or intensity of withdrawal symptoms and the incidence of rapid relapses. It is very important to undertake this process with the collaboration of your doctor. The pharmacist also plays a key role and can provide guidance to monitor withdrawal effects for each medication. Most people who will have withdrawal symptoms will tolerate them without problems for the short duration of these symptoms.


Common and frequent withdrawal symptoms for all classes: anxiety, nervousness, restlessness, sleep problems, greater need to rest, sleep, irritability, fatigue.

Withdrawal symptoms for Wellbutrin:

Withdrawal symptoms usually appear one to seven days after a discontinuation or a significant reduction in dose. About 55% of people feel as if they are going through a period of excitement or depression which is accompanied by raw emotions, anxiety, disturbing dreams and lethargy (numbness of being) temporary. These effects disappear within a few days.


Selective serotonin reuptake inhibitors or SSRIs (Prozac, Luvox, Zoloft, Paxil and Celexa), serotonin and norepinephrine reuptake inhibitors or SNRIs (Effexor, Cymbalta and Pristiq) and bupropion share these symptoms of weaning.


Main psychological withdrawal symptoms:

  • Anxiety

  • Irritability

  • Hustle

  • Insomnia

  • Nightmares or dreams of intense realism (vivid)


Very rarely:

  • Suicidal tendencies or tendencies to want to harm themselves which can appear suddenly at the time of increases or reductions. These symptoms are  often preceded by a period of severe agitation (akathisia).

  • Mania or hypomania


Main physical withdrawal symptoms:

(= flu-like effects)

  • Headaches (headaches)

  • sweating

  • Fatigue

  • General malaise

  • Muscle aches

  • Diarrhea

  • Dizziness, vertigo

  • Tremors

  • Numbness or tingling of the extremities

  • Electric shock sensations in the limbs

  • Blurry vision

  • Very rarely:

  • Concentration or memory problems

  • Movement disorders


Effexor and Paxil have shorter durations of action than other antidepressants. They can give withdrawal reactions that are more difficult to control from day one. It is therefore even more important to gradually reduce the dose.

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