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MAOI antidepressants: Manerix



Mental health problems

  • When other antidepressants have proven ineffective or contraindicated

  • Anxiety disorders

  • Atypical depression (more intense symptoms and aggressiveness)



Physical health issues

  • Allergy or a negative reaction

  • Heart problems

  • High blood pressure

  • Epilepsy

  • Parkinson disease

  • Kidney or liver failure

  • Diet containing tyramine


Mental health problems

Space the intake of an SSRI or an SSRINa and an MAOI by at least 14 days



Marked side effects, should only be used as a last resort



Not indicated for children under 16 years of age

Pregnancy and breast feeding

Birth defects; abstain while breastfeeding

Drugs interactions


Mental health problems

  • Avoid at all costs taking a selective MAOI and non-selective MAOIs together: Nardil or Parnate with Manerix

> Confusion, disorientation

> Hyperactivity

> Chills, tremors, involuntary muscle contractions or  lack of coordination


  • Risky interaction: SSRIs, certain tranquilizers (Buspar)


  • Lithium and tricyclic antidepressants increase the effect of Manerix


  • Antiparkinsonians and Manerix can cause restlessness, disorientation, anxiety, blackouts and hallucinations


Physical health issues

  • May increase the analgesic effect of ibuprofen (Advil, Motrin, Actiprofen, etc.)

  • Risky interaction: narcotics, certain migraine medications (Imitrex)

Side effects

They depend on the dosage and duration of treatment, the metabolism of the individual and the context in which he lives.


  • Dry mouth

  • Dizziness associated with a sudden drop in blood pressure when changing positions

  • Headache






skin problems






In other people, Manerix can have a stimulating effect such as: insomnia, anxiety, agitation and feverishness, aggressive behavior (rare)

Withdrawal symptoms

Psychotropic drugs act in the brain just as they do in the rest of the body; and as we have seen, each person reacts differently. It's the same with weaning; the person's metabolism, the type of drug, the dose as well as the duration of the intake and its half-life, explain that the withdrawal effects are varied. We have listed the potential and main withdrawal symptoms of each class of psychotropic drugs. This list is incomplete, as not all withdrawal effects are listed; moreover, knowledge is rapidly evolving in this area. A person may have no withdrawal symptoms or experience one, a few, or even many. The medication reduction journey is specific to each person, just as each process is unique. For example, a person can take the same medicine twice at the same dose and the effects will be different. Gradual reduction, like removing 10  % of dose per week/month, reduces the frequency or intensity of withdrawal symptoms and the incidence of rapid relapses. It is very important to undertake this process with the collaboration of your doctor. The pharmacist also plays a key role and can provide guidance to monitor withdrawal effects for each medication. Most people who will have withdrawal symptoms will tolerate them without problems for the short duration of these symptoms.


Common and frequent withdrawal symptoms for all classes: anxiety, nervousness, restlessness, sleep problems, greater need to rest, sleep, irritability, fatigue.


Withdrawal symptoms for MAOI antidepressants:

Main psychological withdrawal symptoms:

  • Anxiety

  • Irritability

  • Hustle

  • Insomnia

  • Nightmares or dreams of intense realism (vivid)


Very rarely:

  • Paranoid delirium

  • Hallucinations


Main physical withdrawal symptoms:

  • Drowsiness

  • Volubility (abundance and ease of speech)

  • Difficulties expressing themselves

  • Lethargy (numbness of being, difficulty paying attention)

  • Movement disorders

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