medication / neuroleptics / third generation
3rd generation neuroleptics
Directions
Problems mental health
Schizophrenia
Major depressive disorder in combination with an antidepressant (Rexulti)
Bipolar disorder
Contraindications
Physical health issues
Allergy to aripripazole (Abilify) and brexpiprazole (Rexulti), any ingredient in its preparation, or the composition of its container
Seizures
Lactose allergy
Epileptic seizures
Seniors
Do not give to seniors
Pregnancy and breast feeding
Should not be used during pregnancy, or in women planning to become pregnant, or while breastfeeding
Children and teenagers
Not for use in children under 13 years old
Drugs interactions
The list of medications is very long, it is important to consult the pharmacist, whether prescription or over-the-counter or herbal medicines, as well as supplements, vitamins and contraceptives, nicotine, caffeine, etc.
Mental health problems
Certain MAOIs, tricyclic and heterocyclic antidepressants and SSRIs
Lithium
Amphetamines: destroamphetamine (Dexedrine), methylphenidate (Ritalin, Concerta, Biphentin)
Antipsychotics (Haldol, Seroquel, Largactil, Zyprexa, Risperdal)
Physical health issues
Antiepileptics
Antimigraine drugs (triptans)
Antihistamines
Macrolide antibiotics (azithromycin, erythromycin, clarithromycin)
Muscle relaxants
Statins to treat high cholesterol levels.
Medicines for high blood pressure
It is not advisable to consume alcohol and illicit and controlled drugs.
Side effects
They depend on the dosage and duration of treatment, the metabolism of the individual and the context in which he lives.
Head
Headache
Drowsiness
Dizziness
Dry mouth
Sleep
Sleep disorder
drowsiness
Members
Tremors
Skin rash
Dorsalgia (back pain located at the level of the dorsal vertebrae) or muscle pain
Sexuality
Hypersexuality: continuous and persistent search for sexual pleasure
Abdomen
Nausea, vomiting
Constipation
Stomach pains
gastric pain
Constipation
Weight
Weight gain
Psychological
Restlessness, anxiety
Risk of gambling addiction
Others
Stop taking the drug if:
Seizures
Priapism (persistent erection and painful appearing without sexual arousal)
Urticaria and breathing difficulties
Sudden feeling of weakness or numbness experienced in the face, an arm or a leg
Difficulty speaking
Vision problems
Rarer side effects (call your doctor soon):
Head
Muscle twitching or abnormal movements of the tongue or face
Difficulty swallowing
Symptom of an infection (cough, sore throat, fever, chills)
Members
Extrapyramidal effects (abnormal body movements, shaking, stiffness)
Sexuality
Uncontrollable sexual behaviors
Blood
Signs of a blood clot
Symptoms of high blood sugar (increased thirst or hunger, weight loss, general weakness, increased urination)
Diabetes
Psychological
Restlessness, anxiety
Compulsive gambling
Others
Tardive dyskinesia
Neuroleptic malignant syndrome: characterized by altered mental status (confusion), muscle rigidity, hyperthermia (high body temperature) and neurovegetative hyperactivity (sleep disturbance, irritability, difficulty concentration, hypervigilance and startle reactions)
Low blood pressure
Epileptic seizures
Heart rhythm abnormality
Brownish or discolored urine
Monitoring and medical surveillance
Measure blood glucose and body weight before starting treatment
Clinical monitoring of weight, blood glucose and lipid parameters at regular intervals thereafter
Perform a complete blood count before implantation en route to treatment and then periodically during treatment
Monitor white blood cell count
In order to reduce the risk of overdose, the smallest possible quantity compatible with an adequate therapeutic approach should be prescribed.
Withdrawal symptoms
Psychotropic drugs act in the brain just as they do in the rest of the body; and as we have seen, each person reacts differently. It's the same with weaning; the person's metabolism, the type of drug, the dose as well as the duration of the intake and its half-life, explain that the withdrawal effects are varied. We have listed the potential and main withdrawal symptoms of each class of psychotropic drugs. This list is incomplete, as not all withdrawal effects are listed; moreover, knowledge is rapidly evolving in this field. A person may have no withdrawal symptoms or experience one, a few, or even many. The medication reduction journey is specific to each person, just as each process is unique. For example, a person can take the same medicine twice at the same dose and the effects will be different. Gradual reduction, like removing 10 % of dose per week/month, reduces the frequency or intensity of withdrawal symptoms and the incidence of rapid relapses. It is very important to undertake this process with the collaboration of your doctor. The pharmacist also plays a key role and can provide guidance to monitor withdrawal effects for each drug. Most people who will have withdrawal symptoms will tolerate them without problems for the short duration of these symptoms.
Common and frequent withdrawal symptoms for all classes: anxiety, nervousness, restlessness, sleep problems, greater need to rest, sleep, irritability, fatigue.
Withdrawal symptoms for neuroleptics :
Withdrawal symptoms appear a few days after the dose is reduced. In the process of progressive reduction according to the method of 10 %, the last step can be particularly difficult. It can be lengthened or split to reduce withdrawal symptoms.
Main psychological withdrawal symptoms:
Withdrawal psychosis
Nervousness or restlessness
Insomnia
Main physical withdrawal symptoms:
Muscle stiffness; body aches (sore all over)
Tremors
Sweat
Runny nose
Nausea, vomiting
Cramps, abdominal pain
Diarrhea
Salivation
Headaches (headaches)
Nightmares
Palpitations
Hypertension
Discovery of tardive dyskinesia (Definition: abnormal and involuntary movements of the tongue, jaw, trunk or extremities whose appearance is related to the taking of neuroleptic drugs. tardive dyskinesia may become irreversible.)
Clozaril carries a higher risk in relation to withdrawal psychosis because its duration of action is short.