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Mood stabilizers: Analgesic

Contraindications ​


Physical health issues

  • Allergy to pregabalin (Lyrica) or any of  its constituents or non-medicinal ingredients

  • Kidney problems

  • heart disease

  • Gastrointestinal problems (constipation, blocked or paralyzed bowel)

  • History of angioedema  (rare variety of hives)



  • The doctor should always prescribe the lowest dose

  • Monitor kidney function


Pregnancy and breast feeding

No adequate comparative studies have been conducted in pregnant women, so  pregabalin (Lyrica) should not be used


Children and teenagers (-18 years old)

Do not prescribe to children (except in combination for epilepsy)


Physical health issues

  • Treatment of associated neuropathic pain:

> Nerve pain from diabetes

> To chronic skin pain from a nerve infected with the virus


> Pain following a spinal cord injury

  • Fibromyalgia

  • Alcoholism

  • Restless legs syndrome (feeling of discomfort in the lower limbs. Affected people feel an irresistible urge to move their legs,  and sometimes the arms, especially during periods of rest or waiting)

  • Vasomotor syndrome (hot flushes, night sweats/menopause)


Mental health problems

  • Obsessive Compulsive Disorders

  • Social phobias

Drugs interactions ​


Greater weight gain with certain antidiabetics (thiazolidinediones)

Side effects​

They depend on the dosage and duration of treatment, the metabolism of the individual and the context in which he lives.  



  • Blurry vision

  • Drowsiness

  • Dizziness

  • Dry mouth



  • Swollen extremities

  • Muscular weakness



Impairment of male fertility



  • Renal failure

  • Gastrointestinal disorders

  • Constipation



Weight gain


Psychological (especially in the first few weeks)

Suicidal behaviors and thoughts



  • Redness of the skin

  • Memory loss

Less common side effects



  • Swelling of the face, mouth, lips, gums, tongue, or neck

  • Difficulty breathing

  • Increased cough



  • Swollen extremities

  • Muscular weakness



  • Extreme tiredness

  • Seizures

  • Decreased urine volume




In case of drug overdose, contact a health care practitioner, hospital emergency department or regional Poison Control Center immediately, even if there is no  of symptoms. There is no specific antidote to Lyrica.

The means used are vomiting or gastric lavage.


  • Symptoms: affective disorder, drowsiness, mental confusion, depression, restlessness and motor instability, seizures.

  • Missed dose: Take the next dose at the usual time. Do not compensate by taking a double dose.


Lyrica was originally prescribed for the treatment of pain caused by nerve damage associated with diabetes, for fibromyalgia, for persistent pain following recovery from rashes caused by shingles, and for pain caused by nerve damage in the spinal cord. spinal. It has analgesic, antiepileptic and anxiolytic activity. Lyrica is excreted mainly via the kidneys. It is therefore necessary to be extremely careful about the dosage and to exercise great surveillance with regard to the functioning of the kidneys.

Withdrawal symptoms

Psychotropic drugs act in the brain just as they do in the rest of the body; and as we have seen, each person reacts differently. It's the same with weaning; the person's metabolism, the type of drug, the dose as well as the duration of the intake and its half-life, explain that the withdrawal effects are varied. We have listed the potential and main withdrawal symptoms of each class of psychotropic drugs. This list is incomplete, as not all withdrawal effects are listed; moreover, knowledge is rapidly evolving in this area. A person may have no withdrawal symptoms or experience one, a few, or even many. The medication reduction journey is specific to each person, just as each process is unique. For example, a person can take the same medicine twice at the same dose and the effects will be different. Gradual reduction, like removing 10  % of dose per week/month, reduces the frequency or intensity of withdrawal symptoms and the incidence of rapid relapses. It is very important to undertake this process with the collaboration of your doctor. The pharmacist also plays a key role and can provide guidance to monitor withdrawal effects for each medication. Most people who will have withdrawal symptoms will tolerate them without problems for the short duration of these symptoms.


Common and frequent withdrawal symptoms for all classes: anxiety, nervousness, restlessness, sleep problems, greater need to rest, sleep, irritability, fatigue.

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